Preserve every molecule. Valorise every litre produced.
In biotechnology, certain molecules represent years of research, considerable investment and exceptional scientific or economic value.
Vaccines, monoclonal antibodies, recombinant proteins, fermentation products or innovative biomolecules — every product loss directly impacts process profitability. Tangential flow filtration therefore plays an essential role. Far more than a simple separation operation, it is a strategic step that concentrates, purifies and secures the product while preserving its value.
At GPC, we design custom tangential flow filtration systems capable of supporting the most demanding processes, from R&D laboratory through to GMP industrial production.
Our objective is simple: maximise the recovery of the product of interest while guaranteeing the highest level of purity.
Maximise yields. Reduce losses.
In modern biotechnological processes, a few percentage points of yield can represent thousands, or even tens of thousands of euros in produced value.
Every purification step must therefore be designed to preserve the molecules of interest as much as possible. GPC tangential flow filtration systems are developed to optimise product recovery throughout the process. Precise control of flow rates, transmembrane pressures and operating conditions limits losses, improves separation performance and preserves the biological activity of sensitive molecules.
Because the best purification is the one that eliminates impurities without sacrificing the product.
More than cleaning: a global optimisation of your resources
Tangential flow filtration is today one of the most effective technologies for purification and concentration operations in biotechnology.
Thanks to a flow running parallel to the filter surface, it limits membrane fouling and maintains high filtration performance over extended periods of use.
GPC systems are particularly well suited to:
- Micro/Ultrafiltration
- Diafiltration/Concentration of biomolecules
- Clarification of culture media
- Sterilising filtration
This versatility makes it an essential tool in modern purification processes.
Preserving quality without compromising product integrity
Many biomolecules are sensitive to heat, chemical treatments or aggressive processes. Tangential flow filtration effectively removes unwanted particles, precipitates, aggregates or microorganisms while preserving the biological properties of the product. This approach offers a particularly effective alternative to conventional sterilisation/concentration/clarification methods when the products of interest are sensitive to temperature, shear or chemicals.
Steam-sterilisable tangential filtration systems can also be integrated to allow the sterilisation of sensitive media without resorting to heat treatments that could compromise their quality.
Full compatibility with market-available membranes
The choice of membrane is often decisive in the overall performance of a process.
Each application has its own specific requirements in terms of material, molecular weight cut-off, geometry or membrane technology. That is why GPC tangential flow filtration systems are designed as open platforms.
Our installations are compatible with all membrane technologies available on the market, as well as with the main international manufacturers.
- Cassette membranes
- Hollow fibre membranes
- Polymeric or ceramic membranes
- Microfiltration applications
- Ultrafiltration or diafiltration
Each project benefits from the technology best suited to its objectives.
This technological independence offers several major advantages:
- Freedom of supplier choice
- Process performance optimisation
- Reduced operating costs
- Supply chain security
- Easier process evolution over time
You remain in control of your technological choices without depending on a proprietary solution.
A solution that evolves with your needs
Processes, products and regulatory requirements evolve.
Your equipment must be able to keep pace.
The systems developed by GPC are designed to support the entire lifecycle of a process, from development phases through to commercial production.
Our solutions can be used for:
- Process development and study
- Clinical trials and GMP production
- Large-capacity industrial installations
This technological continuity facilitates scale-up while limiting the risks associated with process transfer.
Custom design for every application
Every project developed by GPC is designed around the client’s specific needs.
Sanitary architecture, membrane selection, instrumentation, automation, integration into an existing installation or development of a complete skid: every detail is studied to guarantee the best performance.
Systems can incorporate:
- Cleaning-in-place (CIP)
- Sterilisation-in-place (SIP)
- Automated recipe management
- Data acquisition and historisation
- Mobile or fixed solutions
- Full integration into existing production lines
The result is equipment perfectly adapted to your process and industrial objectives.
Automation in the service of process control
GPC tangential flow filtration systems can be equipped with our control environment dedicated to biotechnological processes. Operators benefit from intuitive real-time supervision while process teams have precise control over critical parameters. Data is historised, recipes are secured and performance is fully traceable.
To discover the advanced features of our control solution, visit the page dedicated to CBIO2 software.
Because every molecule matters
In biopharmaceutical processes, the value created is measured not only in volume produced, but also in the quantity of product of interest that is actually recovered and valorised.
At GPC, we design tangential flow filtration systems capable of maximising yields, protecting the most sensitive biomolecules and guaranteeing the technological flexibility essential for the processes of tomorrow.
Effective filtration is not simply about eliminating impurities — above all, it is about preserving what has the most value.